Immunology
Introduction
The Immunology grouping within the Bloomsbury Research Institute comprises researchers studying the host response to infection at the molecular, cellular and population levels.
Our goals are to develop a greater understanding of the mechanisms by which pathogens cause disease (pathogenesis) and of the immune response made by the infected host, and to understand how these processes are regulated to avoid immunopathology.
We aim to apply this knowledge to the development of immunological, chemical or other interventions and to the identification of correlates of immune status and disease susceptibility. Our research encompasses work on viruses, bacteria, protozoa and helminths.
We apply cellular, molecular, genetic and mathematical approaches to the in vitro and in vivo analysis of pathogen-host cell interactions, to the study of infection and immunity at the population level in disease endemic areas, and to the use of epidemiological and mathematical tools to understand pathogen biology and host-pathogen interactions.
Current immunological research within the Institute includes studies of innate and adaptive immune responses to Mycobacterium tuberculosis,Burkholderia pseudomallei, Chlamydia trachomatis, Plasmodium falciparum and Plasmodium knowlesi, leishmaniasis, schistosomiasis, intestinal helminths and human herpes viruses.
Immunology case studies
Understanding malaria
Professor Eleanor Riley’s research at LSHTM has advanced our knowled...